Mary & May Spicule Collagen PDRN Cream is an intensive recovery cream formulated with natural marine-derived micro spicules (1,000 ppm), premium French marine collagen, and CICA PDRN to visibly improve skin volume, texture, barrier strength and elasticity while soothing sensitive skin.

Key benefits

• Micro spicule resurfacing: Contains 1,000 ppm of marine-derived microscopic spicules (80–300 μm), smaller than pores, to intensively improve the appearance of wrinkles, refine pores, and smooth skin texture. (Approx. 90,000–100,000 spicules in 15 g.)
• Volume & elasticity boost: Premium French marine collagen helps plump skin, improve volume and increase elasticity for a firmer look.
• Recovery & regeneration: CICA PDRN targets damaged cells to promote skin recovery and regeneration while fortifying the collagen barrier and soothing irritation.
• Safe 4X formula for sensitive skin: Formulated with 2% Panthenol (Vitamin B5), Ceramide NP, Hyaluronic Acid, and Allantoin to hydrate, repair and calm the skin.
• Clinically proven results: Demonstrated improvements in skin plumpness, barrier function and elasticity in clinical testing.
• Skin irritation test completed: Tested for compatibility with sensitive skin.

Clinical results (selected)

• Skin Plumpness: 119.21%
• Skin Barrier: 111.72%
• Skin (2 mm) Elasticity: 104.35%
• Skin (8 mm) Elasticity: 103.65%

How to use

1. After cleansing, apply an appropriate amount evenly to clean, dry skin.
2. Gently spread following the skin’s texture, then lightly press with your palms to enhance absorption.
3. Use once daily (as the first step of your routine) or as recommended by your dermatologist.

Usage notes & precautions

• For external use only. Avoid direct contact with eyes. If contact occurs, rinse thoroughly with water.
• If irritation or redness develops, discontinue use and consult a physician.
• Contains microscopic marine spicules—do not use on open wounds or severely broken skin.
• Store in a cool, dry place away from direct sunlight.

Key active ingredients

• Marine-derived microscopic spicules (1,000 ppm; 80–300 μm)
• Hydrolyzed (French) marine collagen
• CICA PDRN (for cell recovery & regeneration)
• Panthenol (2%), Ceramide NP, Sodium Hyaluronate, Allantoin

Full ingredients

Aqua (Water), Methylpropanediol, Glycerin, 1,2-Hexanediol, Panthenol, Niacinamide, Caprylic/Capric Triglyceride, Polypropylsilsesquioxane, C14-22 Alcohols, Ammonium Acryloyldimethyltaurate/VP Copolymer, Glyceryl Stearate, Hydrolyzed Collagen, Cetyl Ethylhexanoate, Vinyl Dimethicone, Macadamia Ternifolia Seed Oil, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C12-20 Alkyl Glucoside, Arginine, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Brassica Campestris (Rapeseed) Sterols, Polyglyceryl-10 Laurate, Polyisobutene, Dextrin, Tocopherol, Allantoin, Ethylhexylglycerin, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Cholesterol, Hydrolyzed Sponge, Gardenia Florida Fruit Extract, Xanthan Gum, Butyrospermum Parkii (Shea) Butter, Adenosine, Lauryl Glucoside, Hydrogenated Lecithin, Sodium Hyaluronate, Polyglyceryl-6 Laurate, Disodium EDTA, Caprylyl/Capryl Glucoside, Sorbitan Oleate, Polyglutamic Acid, Myristyl Glucoside, Ceramide NP, Glyceryl Acrylate/Acrylic Acid Copolymer, Stearic Acid, PVM/MA Copolymer, Oleic Acid, Sodium Guaiazulene Sulfonate, Sodium DNA.